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X-ORIGINAL-URL:https://cmc.deusto.eus/
X-WR-CALNAME:cmc.deusto.eus
X-WR-CALDESC:DeustoCCM - Chair of Computational Mathematics at University of Deusto
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BEGIN:VEVENT
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UID:MEC-c70a586e24e85c37424a19296bad06f7@cmc.deusto.eus
DTSTART:20261028T150000Z
DTEND:20261028T170000Z
DTSTAMP:20261022T181800Z
CREATED:20261022
LAST-MODIFIED:20261022
PRIORITY:5
TRANSP:OPAQUE
SUMMARY:IKTrace Seminar: The long and winding road to dementia: Exploring Alzheimer’s disease trajectories through mathematical modelling
DESCRIPTION:IKTrace Seminar: The long and winding road to dementia: Exploring Alzheimer’s disease trajectories through mathematical modelling\nDate: Wed. October 28, 2026\nEvent: IKTrace Seminar (IMAT-CCM)\nThe IKTrace Seminar (IMAT-CCM), is a new initiative conceived as a forum for academic exchange, discussion, and collaboration within and beyond our mathematics research group.\nTitle: The long and winding road to dementia: Exploring Alzheimer’s disease trajectories through mathematical modelling\nSpeaker: Giulio Bonifazi\nAffiliation: University of Deusto\nAbstract. Alzheimer’s disease (AD) is a complex neurodegenerative disease characterized by biological changes that can begin years before the onset of clinical symptoms. Among the processes associated with its early stages, neuronal hyperactivity has emerged as a potential contributor to disease progression. One possible mechanism involves amyloid-β (Aβ)-mediated alterations in glutamate uptake by astrocytes, non-neuronal cells that play a key role in regulating neuronal activity. However, the interplay between Aβ accumulation, glutamate dynamics, and neuronal hyperactivity remains incompletely understood.\nMathematical modelling provides a framework for investigating these mechanisms and exploring how their interactions may shape disease progression. In this seminar, we will introduce a biophysical model describing the interplay between three main pathways: glutamate-mediated neuronal activity, Aβ-dependent glutamate uptake, and activity-dependent Aβ production. By integrating these processes into a unified mathematical framework, the model allows us to investigate how their interactions can give rise to different trajectories of AD involving neuronal hyperactivity. \nFinally, we will discuss how local tissue properties shape the different trajectories of AD, illustrating why disease progression may follow different paths across the brain.\nWHERE\nOn-site: Room E313.\nESIDE building, 3rd floor. University of Deusto\nUnibertsitate Etorb., 24007, Deusto, 48014 Bilbao, Bizkaia\n\nPoster\nThe seminar aims to strengthen mutual awareness of ongoing research lines, teaching interests, and interdisciplinary initiatives that will help identify shared interests, foster new synergies, and encourage future collaborations among colleagues from different areas of the Faculty of Engineering at University of Deusto.\n
URL:https://cmc.deusto.eus/events-calendar/iktrace-seminar-the-long-and-winding-road-to-dementia/
CATEGORIES:IKTrace Seminar
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