Abstract. In this paper, we consider the infinite dimensional linear control system describing population models structured by age, size, and spatial position. The diffusion coefficient is degenerate at a point of the domain or both extreme points. Moreover, the control is localized in the space variable as well as with respect to the age and size. For each control support, we give an estimate of the time needed to control the system to zero. We establish the null controllability of the model by using a technique that avoids the explicit use of parabolic Carleman estimates. Indeed, our argument relies on a method that combines final-state observability estimates with the use of the characteristic method.